Possible Applications of Adrenocorticotrophic Hormone (ACTH) and Cortisone in Syphilis

Possible applications of adrenocorticotrophic hormone (ACTH) and cortisone in syphilis.

Pituitary adrenocorticotrophic hormone (ACTH) and cortisone have already become established as important therapeutic agents in many diseases, and an enormous literature has accumulated since their effect in rheumatoid arthritis was announced by Hench and others (1949). After an initial wave of uncritical enthusiasm, the applications and limitations of these hormones are now being realized, but ...

Isolated adrenocorticotrophic hormone (ACTH) deficiency associated with acute adrenal crisis.

A 37 year old black female presented with congestive cardiac failure, 2 months postpartum. She developed spontaneous hypoglycaemia and symptoms of acute adrenal crisis (hypotension, nausea, abdominal pain and tachycardia with small thready pulse), which responded to i.v. dextrose, sodium chloride and hydrocortisone. Biochemical investigations revealed low serum cortisol and plasma adrenocortico...

Cortisone and ACTH.

Effects of exogenous adrenocorticotropic hormone (ACTH) upon pituitary ACTH concentration after prolonged cortisone treatment and stress.

Symptoms and metabolic abnormalities closely resembling those of hypoadrenalism have been reported following cessation of prolonged treatment with adrenal steroids (1-5). Sudden death following surgery has been reported in association with this syndrome and has been ascribed to failure of the hypothalamic-pituitary-adrenal system to respond to stress (6-9). Since prolonged administration of cor...

Metabolism of dehydroascorbic acid and the effect of adrenocorticotrophic hormone and cortisone.